METHODS FOR TREATMENT AND PREVENTION OF TAUOPATHIES AND AMYLOID BETA AMYLOIDOSIS BY MODULATING CRF RECEPTOR SIGNALING
摘要
Methods for treating or preventing tauopathies and/or Aß amyloidosis by modulating CRF receptor signaling. Accumulation of hyperphosphorlyated tau protein in the CNS may be reduced by administration of CRF-Rl selective antagonists and/or CRF-R2 selective agonists. For example, in some aspects, methods for preventing the onset of Alzheimer's disease by administration of CRF-Rl selective antagonist are provided.
申请公布号
WO2008157302(A2)
申请公布日期
2008.12.24
申请号
WO2008US66848
申请日期
2008.06.13
申请人
RESEARCH DEVELOPMENT FOUNDATION;RISSMAN, ROBERT, A.;LEE, KUO-FEN;VALE, WYLIE, W.;SAWCHENKO, PAUL, E.
发明人
RISSMAN, ROBERT, A.;LEE, KUO-FEN;VALE, WYLIE, W.;SAWCHENKO, PAUL, E.