Treatment of erectile dysfunction and other indications

摘要

The present invention generally relates to the transdermal delivery of various compounds. In some aspects, transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising a phosphodiesterase type 5 inhibitor and/or a salt thereof, and optionally, a hostile biophysical environment and/or a nitric oxide donor. In some cases, the composition may be stabilized using a combination of a stabilization polymer (such as xanthan gum, KELTROL® BT and/or KELTROL® RD), propylene glycol, and a polysorbate surfactant such as Polysorbate 20, which combination unexpectedly provides temperature stability to the composition, e.g., at elevated temperatures such as at least 40° C. (at least about 104° F.), as compared to compositions lacking one or more of these.

主权项

1. A composition for topical delivery to the skin of a subject, the composition being a cream, gel, or lotion, the composition comprising:
a nitric oxide donor comprising L-arginine and/or L-arginine hydrochloride at a concentration of about 2.5% to about 15% by weight; an ionic salt at a concentration of at least about 0.25 M; xanthan gum at no more than about 1 wt %; propylene glycol at at least about 6% by weight; a polysorbate surfactant comprising Polysorbate 20 at no more than about 3 wt %; and a pharmaceutical agent and/or salt thereof for treating sexual dysfunction at a concentration of at least about 0.1% by weight of the composition, the pharmaceutical agent having a structure selected from the group consisting of: