METFORMIN-COMPRISING COMPOSITIONS FOR REDUCING NEPHROTOXICITY CAUSED BY IMMUNOSUPPRESSIVE DRUGS AND FOR THE PREVENTION OR TREATMENT OF IMMUNE DISEASES

摘要

The present invention relates to a composition comprising metformin for alleviating nephrotoxicity caused by an immunosuppressive drug and a composition for preventing or treating immune diseases comprising the same. More particularly, the present invention relates to a composition for reducing nephrotoxicity caused by an immunosuppressive drug, which comprises metformin as an active ingredient, a pharmaceutical composition for preventing or treating immune diseases, which comprises metformin and a calcineurin inhibitor as active ingredients, and a pharmaceutical complex formulation for preventing or treating immune diseases, which comprises metformin and a calcineurin inhibitor as active ingredients, administered simultaneously, individually or sequentially in a predetermined order. The composition according to the present invention effectively alleviates malfunction of the kidney caused by the side effect of a conventional immunosuppressive drug and is useful for increasing the effect of treating diseases requiring immunosuppression. Further, the present invention suggests various methods including administering a conventional immunosuppressive drug in combination with metformin to reduce the side effect of nephrotoxicity of the conventional immunosuppressive drug and to maximize the effect of immunosuppression or immunoregulation. Thus, the composition is useful for preventing or treating xenotransplantation rejection, autoimmune diseases, inflammatory diseases, or the like.