发明名称 |
Bisulfate of janus kinase (JAK) inhibitor and preparation method therefor |
摘要 |
The present invention relates to a bisulfate of a Janus kinase (JAK) inhibitor and a preparation method therefor. More specifically, the present invention relates to a (3aR,5s,6aS)—N-(3-methoxyl-1,2,4-thiadiazole-5-group)-5-(methyl(7H-pyrrolo[2,3-d]pyrimidine-4-group)amino)hexahydrocyclopenta[c]pyrrole-2(1H)-formamide bisulfate shown in the formula (I), a preparation method therefor, and an application thereof. The bisulfate shown in the formula (I) can be well suitable as a Janus kinase (JAK) inhibitor in clinical work for treating rheumatism or rheumatoid arthritis.; |
申请公布号 |
US9422300(B2) |
申请公布日期 |
2016.08.23 |
申请号 |
US201414895117 |
申请日期 |
2014.05.05 |
申请人 |
Jiangsu Hengrui Medicine Co., Ltd. |
发明人 |
Sun Piaoyang;Wu Guaili;Gao Xiaohui;Shen Lingjia |
分类号 |
C07D487/04 |
主分类号 |
C07D487/04 |
代理机构 |
Panitch Schwarze Belisario & Nadel LLP |
代理人 |
Panitch Schwarze Belisario & Nadel LLP |
主权项 |
1. (3aR,5s,6aS)—N-(3-methoxyl-1,2,4-thiadiazol-5-yl)-5-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxamide bisulfate of formula (I) |
地址 |
Lianyungang, Jiangsu CN |