Rapid infusion of autologous bone marrow derived stem cells

摘要

The present invention relates to a method and composition for the aspiration, processing, testing and infusion of bone marrow derived stem cells, as an adjuvant treatment in cardiovascular disorders. More specifically, the invention provides for the methods and compositions for the aspiration, analysis, processing, infusate preparation and infusion of bone-marrow derived stem cells, particularly in a rapid point-of-care environment, wherein a centrifugal fractionation and optically monitored separation of the bone marrow yield desired cellular product in the desired concentration and viscosity.

主权项

1. A composition comprising:
(a) a first cell population that comprises bone marrow stem cells and/or progenitor cells, (b) an anticoagulant, (c) an aqueous buffer and/or an autologous serum and/or an autologous plasma fraction, and (d) red blood cells, wherein the composition has a viscosity of 1.5-3.5 centipoise (cP) measured at 37° C.