| 主权项 |
1. A method for diagnosing a patient's ovarian cancer disease health state or change in health state, or for diagnosing ovarian cancer, or the risk of ovarian cancer in a patient, the method comprising the steps of:
a) analyzing at least one blood sample from said patient using a high resolution mass spectrometer to obtain accurate mass intensity data; b) comparing the accurate mass intensity data to corresponding data obtained from one or more than one reference sample to identify an increase or decrease in accurate mass intensity; and c) using said increase or decrease in accurate mass intensity for diagnosing a patient's ovarian cancer health state or change in health state, or for diagnosing ovarian cancer, or the risk of ovarian cancer in said patient, wherein the accurate mass intensity is measured at or ±5 ppm of a hydrogen and electron adjusted accurate mass, or neutral accurate mass, in Daltons, selected from the group consisting of: 492.3841; 590.4597, 447.3436, 450.3735, 502.4055; 484.3793, 577.4801, 490.3678, 548.4442, 466.3659, 494.3973, 576.4762, 592.4728, 464.3531, 467.3716, 448.3565, 574.4597, 594.4857, 595.4889, 594.4878, 518.3974, 574.4638, 504.4195, 534.3913, 576.4768, 519.3329, 532.4507, 538.4270, 566.4554, 440.3532, 520.4131, 596.5015, 597.5070, 530.4370, 541.3148, 510.3943, 474.3736, 575.4631, 578.4930, 512.4083, 597.5068, 522.4323, 478.4050, 596.5056, 593.4743, 568.3848, 598.5121, 558.4653, 550.4609, 559.4687, 578.4909, 783.5780, 850.7030, 540.4393, 446.3413, 482.3605, 521.4195, 524.4454, 540.4407, 541.4420, 579.4967, 580.5101, 610.4853, 616.4670, 749.5365, 750.5403, 784.5813, 785.5295, 814.5918, 829.5856, 830.5885, 830.6539, 851.7107, 244.0560, 306.2570, 508.3783, 513.4117, 521.3479, 536.4105, 565.3393, 570.4653, 618.4836, 757.5016, 784.5235, 852.7242, 317.9626, 523.3640, 546.4305, 555.3101, 577.4792, 726.5454, 568.4732, 824.6890, 469.3872, 534.4644, 723.5198, 886.5582, 897.5730, 226.0687, 531.3123, 558.4666, 566.3433, 569.4783, 595.4938, 876.7223, 518.3182, 537.4151, 545.3460, 552.3825, 557.4533, 572.4472, 581.5130, 699.5206, 750.5434, 787.5446, 826.7051, 596.4792, 675.6358, 727.5564, 770.5108, 506.3212, 728.5620, 813.5889, 647.5740, 725.5376, 327.0325, 496.3360, 591.3542, 648.5865, 676.6394, 805.5606, 827.7086, 887.5625, 1016.9298, 517.3148, 551.4658, 724.5245, 755.4866, 830.5894, 854.5886, 567.3548, 853.5853, 593.4734, 723.5193, 1017.9341, 649.5898, 560.4799, 751.5529, 481.3171, 556.4504, 646.5709, 749.5402, 794.5128, 821.5717, 829.5859, 840.6067, 496.4165, 729.5726, 807.5762, 819.5553, 626.5286, 857.6171, 808.5794, 852.7196, 505.3227, 566.3433, 592.3570, 541.3422, 542.3452, 779.5438, 785.5936, 786.5403, 758.5654, 1018.9433, 495.3328, 735.6555, 752.5564, 382.1091, 569.3687, 757.5618, 837.5885, 879.7420, 300.2099, 794.5423, 806.5644, 877.7269, 522.4640, 589.3401, 320.2358, 339.9964, 559.4699, 878.7381, 749.5354, 783.5139, 243.0719, 803.5437, 812.5768, 1019.9501, 829.5596, 831.5997, 523.4677, 780.5473, 853.7250, 899.5874, 205.8867, 519.3320, 825.5544, 562.5001, 194.0804, 273.8740, 752.5579, 570.3726, 783.5783, 283.9028, 552.4048, 763.5158, 781.5612, 779.5831, 817.5377, 259.9415, 612.5005, 763.5144, 770.5701, 863.6872, 509.3493, 782.5087, 552.4788, 832.6027, 782.5649, 822.5750, 828.5734, 923.5882, 793.5386, 501.3214, 777.5679, 368.1653, 809.5938, 751.5548, 804.5470, 569.3691, 568.3574, 827.5698, 786.5967, 753.5669, 759.5159, 855.6012, 858.7902, 756.4904, 580.5345, 784.5808, 853.5864, 560.4828, 573.4855, 587.3229, 560.4816, 952.7568, 801.5551, 741.5306, 773.5339, 854.5903, 847.5955, 736.6583, 529.3167, 810.5401, 628.5425, 518.4345, 769.5644, 990.8090, 269.9704, 804.7219, 216.0401, 300.2084, 411.3186, 746.5561, 632.5753, 895.5578, 688.5294, 382.2902, 758.5088, 776.6068, 609.3242, 392.2940, 747.5204, 218.0372, 811.5733, 826.5577, 265.8423, 675.6374, 570.4914, 202.0454, 856.6046, 276.2096, 328.2629, 702.5675, 803.5684, 804.5716, 624.5134, 721.6387, 247.9576, 440.3898, 926.7366, 839.6034, 764.5187, 722.6422, 900.5895, 590.3429, 724.5498, 769.4958, 857.6185, 777.5299, 333.8296, 755.5476, 313.9966, 599.5004, 810.5970, 801.5297, 830.5650, 629.5452, 716.4981, 858.6210, 524.4725, 534.4558, 861.5265, 670.5708, 748.5280, 520.4502, 686.5125, 690.5471, 625.5163, 859.6889, 1251.1152, 763.5150, 269.8081, 829.5620, 745.4973, 541.3138, 1019.3837, 627.5306, 354.1668, 695.6469, 707.6257, 641.4915, 772.5269, 444.3598, 720.2576, 709.2595, 738.5448, 761.5839, 831.5750, 672.5865, 895.5590, 247.9579, 589.3404, 572.4818, 673.5892, 880.7526, 772.5857, 881.7568, 747.5233, 215.9155, 521.4524, 341.8614, 768.4945, 598.4961, 430.3083, 494.4343, 912.8233, 343.8589, 416.3670, 802.5328, 278.2256, 775.5534, 767.5455, 217.9125, 838.7228, 363.3499, 263.8452, 371.3538, 828.7205, 872.5557, 871.5528, 872.7844, 922.8228, 796.5293, 871.5940, 767.5821, 950.7386, 561.4871, 588.3282, 174.1408, 760.5816, 825.5547, 837.7180, 492.4185, 671.5722, 541.3433, 760.5223, 452.2536, 663.5212, 744.4942, 302.2256, 751.5514, 775.5531, 798.6773, 432.3256, 633.3235, 808.5798, 615.3540, 857.8044, 858.7341, 804.7208, 874.5514, 300.2676, 756.5512, 369.3474, 305.2439, 660.5006, 748.5721, 309.3035, 910.7247, 252.2096, 829.7242, 255.0896, 807.5768, and combinations thereof, and wherein said increase or decrease in accurate mass intensity in the blood sample from the patient relative to the corresponding data obtained from said one or more than one reference sample indicates that the patient has ovarian cancer or is at risk of ovarian cancer. |
