| 摘要 |
The disclosure provides, among other things, compositions and methods useful for maintaining splicing fidelity in a cell. The compositions can include a compound that modulates the expression level or activity of one or more components of the spliceosome complex in a cell. In some embodiments, the compound is useful for restoring the expression level or activity of one or more splicing complex components to the expression level or activity present in the cell at an earlier chronological age. In some embodiments, the compound is useful for modulating the expression level or activity of one or more splicing complex components in the cell to the expression level or activity present in the cell under caloric restriction. |
