Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof

摘要

The present invention relates to novel pyrimidine hydroxy amide compounds, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.

主权项

1. A method of treating multiple myeloma in a subject comprising administering to the subject a compound of formula VI: or a pharmaceutically acceptable salt thereof,wherein,
Rx and Ry together with the carbon to which each is attached, form a cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, tetrahydropyranyl, piperidinyl, piperazinyl, morpholinyl, tetrahydrofuranyl, tetrahydrothiophenyl, pyrrolidinyl, oxazolidinyl, or imidazolidinyl; each RA is independently alkyl, alkoxy, cycloalkyl, aryl, heterocycloalkyl, heteroaryl, arylalkyl, heteroarylalkyl, haloalkyl, haloalkoxy, halo, OH, —NO2, —CN, or —NH2; and m is 0, 1, or 2.