| 摘要 |
<p>The present invention relates to the identification of a specific endogenous ligand for the human G-protein coupled receptor bombesin receptor subtype 3 (hereinafter referred to as BRS-3 receptor ('BRS-3'), and in particular the invention relates to the use of this receptor in drug discovery, preferably with respect to certain dysfunctions or diseases, and furthermore to the drugs that playa role in preventing, ameliorating or correcting said dysfunctions or diseases. In this context also described are BRS-3 polynucleotides, BRS-3 polypeptides encoded by them, and the use of such polynucleotides and polypeptides, and their production. The invention also relates to inhibiting or activating the action of such polynucleotides and polypeptides, to a vector containing said polynucleotides, a host cell containing such vector and transgenic animals where the BRS-3 gene is either overexpressed, misexpressed, underexpressed or suppressed (knock-out animals). The invention further relates to a method for screening compounds capable to act as an agonist or an antagonist of said G-protein coupled receptor BRS-3 or which modulate the activity of said G-protein coupled receptor BRS-3, and to an endogenous ligand of BRS-3 and the use of this ligand in the treating, preventing, ameliorating or correcting said dysfunctions or diseases related to the activities of BRS-3 in relation to its specific endogenous ligand.</p> |
