DESIGN AND SYNTHESIS OF NOVEL INHIBITORS OF ISOPRENOID BIOSYNTHESIS (ISPF)

摘要

Antibacterial and antimalarial IspF inhibitor compounds and compositions are described. Methods include administering described compounds and compositions to treat bacterial or parasitic infections and to inhibit parasite or bacterial growth.

主权项

1. A compound of Formula I wherein X is N and Y is C, or X is C and Y is N; R1 is OH or OR5, wherein R5 is lower alkyl, acyl, CH2OCOCH3, or a prodrug; R2 is alkyl, alkylaryl, arylheteroaryl, or heteroaryl; R3 is H or lower alkyl; and
R4 is H or lower alkyl, or a pharmaceutically acceptable salt thereof.