| 摘要 |
PURPOSE:To obtain the new tripeptide effective as an active ingredient for a therapeutic agent for wound, having proliferation promoting activity for fibroblasts free from undesirable subsidiary activity, comprising L-lysyl-glycyl-L- histidine or its metal complex. CONSTITUTION:This new tripeptide is L-lysyl-glycyl-L-histidine or its metal complex [e.g. copper(II) complex], has proliferation discount activity for fibroblast, multiplies fibroblasts, multiplies fibroblasts, attracts fibroblasts to an affected site and has promoting action on restoration of wound or its metal complex. Consequently, the tripeptide or its metal complex is useful as an active ingredient for a therapeutic agent for wound free from undesirable secondary activity. The compound is obtained by a solid-phase synthesizing method of a peptide, using a granular resin comprising a styrene-divinylbenzene copolymer as a solid carrier, successively bonding a protecting amino acid toward N-end of a peptide, eliminating the obtained peptide from the solid phase, deprotecting and purifying by high-performance liquid chromatography. |
