<p>The present invention relates to peptides corresponding to human growth hormone (hGH) 177-191 or a lipid metabolising subfragment or analogue thereof containing a disulphide bond, with the proviso that the peptide is not intact, full length growth hormone, and there use in modulating lipid metabolism and promoting weight reduction when administered at a dose of 0.01 - 2 mg per day. Dosage units comprising the peptide are also provided. The invention also relates to use of the peptides in treating glucose intolerance and improving lipid profiles.</p>
