ANTIVIRAL COMBINATIONS COMPRISING LAMIVUDINE AND LOBUCAVIR

摘要

The present invention relates to therapeutic combinations comprising (2R,cis)-4- amino-1- (2-hydroxymethyl -1,3-oxathiolan -5-yl) -pyrimidin-2 -one (lamivudine) and a second therapeutic agent [1R- (1 alpha ,2 beta ,3 alpha )] -2-amino -9-[2,3-bis (hydroxymethyl) cyclobutyl] -1,9 -dihydro -6H- purin- 6-one, (lobucavir). The present invention is also concerned with pharmaceutical compositions containing said combinations and their use in the treatment of HBV infections including infections with HBV mutants bearing resistance to nucleoside and/or non-nucleoside inhibitors of the replication of the hepatitis B virus.