| 主权项 |
1. A compound having the structure of Formula I, or a pharmaceutically acceptable salt thereof:wherein:
X is a (5- to 14-membered)heteroaryl containing 1-3 heteroatoms; R1 is selected from the group consisting of hydrogen, halogen, cyano, (C1-C6)alkyl, (C1-C6)alkoxy, (C3-C8)cycloalkyl, and (C2-C6)alkenyl; wherein the (C1-C6)alkyl, (C1-C6)alkoxy, (C3-C8)cycloalkyl, and (C2-C6)alkenyl are optionally substituted with one to three substituents each independently selected from the group consisting of fluoro, hydroxyl and (C1-C6)alkoxy; R2a and R2b, at each occurrence, are independently selected from the group consisting of hydrogen, fluoro, cyano, (C1-C6)alkyl, halo(C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C8)cycloalkyl, and phenyl; wherein the (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C8)cycloalkyl, and phenyl are optionally substituted with one to three substituents each independently selected from the group consisting of cyano, (C1-C3)alkyl and fluoro; or R2a and R2b together with the carbon to which they are attached form a (C3-C8)cycloalkyl or a (4- to 10-membered)heterocycloalkyl, wherein the (C3-C8)cycloalkyl and the (4- to 10-membered)heterocycloalkyl are optionally substituted with one to three R8; A is a (C6-C10)aryl or a (5- to 14-membered)heteroaryl; wherein the (C6-C10)aryl and (5- to 14-membered)heteroaryl are optionally substituted with one to five R13; L, when present, is selected from the group consisting of oxygen, NR10, sulfur, and (C3-C8)cycloalkyl, wherein the (C3-C8)cycloalkyl is optionally substituted with one to three substituents independently selected from the group consisting of halogen and (C1-C3)alkyl; R3 is selected from the group consisting of hydrogen, —(C(R12)2)t—(C3-C8)cycloalkyl, —(C(R12)2)t-(4- to 10-membered)heterocycloalkyl, —(C(R12)2)t—(C6-C10)aryl, and —(C(R12)2)t-(5- to 14-membered)heteroaryl; wherein the (C3-C8)cycloalkyl, (4- to 10-membered)heterocycloalkyl, (C6-C10)aryl, and (5- to 14-membered)heteroaryl moieties are optionally substituted with one to five R11; R4a and R4b are each independently selected from the group consisting of hydrogen and (C1-C6)alkyl, wherein the (C1-C6)alkyl is optionally substituted with one to three substituents independently selected from the group consisting of cyano and fluoro; or R4a and R4b together with the carbon to which they are attached form a (C3-C8)cycloalkyl, wherein the (C3-C8)cycloalkyl is optionally substituted with one to three substituents each independently selected from the group consisting of cyano, fluoro, trifluoromethyl and (C1-C6)alkyl; R5a and R5b, at each occurrence, are independently selected from the group consisting of hydrogen and (C1-C6)alkyl, wherein the (C1-C6)alkyl is optionally substituted with one to three substituents each independently selected from the group consisting of cyano and fluoro; or R5a and R5b together with the carbon to which they are attached form a (C3-C8)cycloalkyl, wherein said (C3-C8)cycloalkyl is optionally substituted with one to three substituents each independently selected from the group consisting of cyano, fluoro, trifluoromethyl and (C1-C6)alkyl; R6 and R7 are each independently selected from the group consisting of hydrogen, cyano, halogen, trifluoromethyl, (C1-C6)alkyl, and —OR9; provided that R6 and R7 cannot both be hydroxyl; R8, at each occurrence, is independently selected from the group consisting of cyano, halogen, trifluoromethyl, hydroxyl and (C1-C6)alkyl; R9 is selected from the group consisting of hydrogen and (C1-C6)alkyl; wherein the (C1-C6)alkyl is optionally substituted with one to three substituents each independently selected from the group consisting of cyano and fluoro; R10 is independently selected from the group consisting of hydrogen and (C1-C6)alkyl; wherein the (C1-C6)alkyl is optionally substituted with one to three halogen; R11, at each occurrence, is independently selected from the group consisting of halogen, cyano, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkoxy(C1-C6)alkyl, halo(C1-C6)alkoxy, (C3-C8)cycloalkyl, (5- to 10-membered)heterocycloalkyl, —N(CH3)2, oxo, and SF5; wherein the (C3-C8)cycloalkyl and (5- to 10-membered)heterocycloalkyl are optionally substituted with one to three halogen; R12, at each occurrence, is independently selected from the group consisting of hydrogen, halogen, cyano, (C1-C6)alkyl, and —SF5; wherein the (C1-C6)alkyl is optionally substituted with one to three fluoro; R13, at each occurrence, is independently selected from the group consisting of halogen, cyano, (C1-C6)alkyl, (C1-C6)alkoxy, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, (C1-C6)alkylthio, (C3-C8)cycloalkyl, —SF5, —Si(CH3)3, and propynyloxybenzoylbenzyl; m is an integer selected from 0 or 1; t is an integer selected from 0, 1, 2, 3 or 4; z is an integer selected from 1 or 2; and y is an integer selected from 1, 2, 3 or 4. |
