β-AMYLOID FORMATION INHIBITORS

摘要

Compounds represented by the following general formula which are useful in treating Alzheimer's disease, etc. because of having an effect of inhibiting the formation of β-amyloid: R1-Y-NH-A-CO-R2 wherein R1 represents optionally substituted aryl, an optionally substituted unsaturated heterocycle or optionally substituted alkyl; R2 represents optionally substituted amino, optionally substituted alkoxy or hydroxy; -Y- represents -CO-, etc.; and -A- represents a group of formula (I), etc. wherein one of R?3 and R4¿ represents hydrogen, halogeno, -S(O)¿n?-X (wherein n is 0, 1 or 2; and X represents optionally substituted alkyl, optionally substituted aryl or an optionally substituted unsaturated heterocycle), optionally substituted alkyl or optionally substituted aryl, while the other one of R?3 and R4¿ represents optionally substituted aryl or an optionally substituted unsaturated heterocycle.