Activation of cellular immunity with antigenic proteins and hydrophobized polysaccharides, which have modified alkyl or cholesterol groups

摘要

A cell with cellular immunity induced by reacting in vitro a complex comprising a hydrophobized polysaccharide, at a ratio of 0.5 to 5 per 100 saccharide units that constitute the polysaccharide, wherein the primary hydroxyl group is a group represented by the formula: -O-(CH2)mCONH(CH2)nNH-CO-O-R wherein R represents an alkyl group or a sterol residue; m represents 0 or 1; and n represents a positive integer; and an antigen with an antigen-presenting cell such as a dendritic cell. The antigen-presenting cell has cellular immunity induced more efficiently than conventional vaccines.