The invention is directed to the use of IL-1-like fusion polypeptides to increase the solubility and activity of recombinant polypeptides. The invention includes a nucleic acid encoding a fusion polypeptide comprising an interleukin-1-like polypeptide and a polypeptide of interest and the method of using such a nucleic acid to produce recombinant fusion polypeptides.
申请公布号
US5563046(A)
申请公布日期
1996.10.08
申请号
US19930100744
申请日期
1993.08.02
申请人
CELTRIX PHARMACEUTICALS, INC.
发明人
MASCARENHAS, DESMOND;ZHANG, YANG;OLSON, PAMELA S.;OLSEN, DAVID R.;CARRILLO, PEDRO A.
