Targeted carriers for drug delivery across the gastrointestinal epithelium

摘要

A system and method for transcellular transport of compositions containing agents (e.g., research, analytical, reporter or molecular probes, diagnostic and therapeutic agents, biologically active agents, research agents, analytical agents, imaging agents, monitoring agents, enzymes, proteins, peptides, nucleic acids, lipids, sugars, hormones, lipoproteins, chemicals, viruses, bacteria, cells, including modified cells, biosensors, markers, antibodies and/or ligands) across the gastrointestinal epithelial layer including use of a composition containing the agent and a targeting moiety, specific for a determinant at the target location. An exemplary composition of the system includes an anti-ICAM antibody targeting moiety, specific for targeting ICAM-1. The system enables effective, versatile, and safe targeting and transport of agents. The system is useful in research applications, as well as in the context of translational science and clinical interventions.

主权项

1. A composition for oral administration to a subject, the composition comprising:
a) a targeting moiety comprising an anti-ICAM antibody, wherein the targeting moiety recognizes and binds to ICAM-1 on a gastrointestinal epithelial cell; b) an agent, and c) a protective agent effective to protect the targeting moiety and agent of b) from degradation prior to arrival at the locus of the gastrointestinal epithelial cell, wherein the targeting moiety and the agent of b) are constituted so that they are transported across the gastrointestinal epithelium after arrival at the locus of the gastrointestinal epithelial cell.