AGENTS FOR THE TREATMENT OF DISEASES CAUSED BY PARASITIC PROTOZOA AND NEOPLASTIC DISEASES

摘要

The compounds 5'-deoxy-5'-(hydroxyethylthio)adenosine (HETA); 5'-deoxy-5'- (monofluoroethylthio)adenosine (MFE- TA); 5'-deoxy-5'-(chloroethylthio)adenosine (CETA); 5'-deoxy-5'- (bromoethylthio)adenosine (BETA); 5-deoxy-5-(monofluoroe- thylthio)ribose (MFETR); 5-deoxy-5-(chloroethylthio)ribose (CETR); 5-deoxy-5 - (bromoethyithio)ribose (BETR) and 5-deoxy- 5-(hydroxyethylthio)ribose (HETR), are described as well as their uses in treating infections caused by 5'-deoxy-5'-methylthioad- enosine (MTA) phosphorylase-containing pathogenic microorganisms; in treatin g infections caused by 5-deoxy-5-methylthiori- bose (MTR) kinase-containing pathogenic microorganism; and for treating neoplastic diseases.