发明名称 |
5'-MODIFIED BICYCLIC NUCLEIC ACID ANALOGS |
摘要 |
The present invention provides 5'-modified bicyclic nucleoside analogs and oligomeric compounds comprising at least one of these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 5'-carbon. These bicyclic nucleoside analogs are useful for enhancing properties of oligomeric compounds including for example enhanced nuclease resistance.
|
申请公布号 |
US2007287831(A1) |
申请公布日期 |
2007.12.13 |
申请号 |
US20070747057 |
申请日期 |
2007.05.10 |
申请人 |
ISIS PHARMACEUTICALS, INC |
发明人 |
SETH PUNIT P.;SWAYZE ERIC E. |
分类号 |
C07H19/00 |
主分类号 |
C07H19/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|