7-{4-[(2S)-2-({[TRANS-4-(AMINOMETHYL)CYCLOHEXYL]CARBONYL}AMINO)-3-(PHENYLAMINO)-3-OXOPROPYL]PHENYL}-6-METHYL-4-OXO-1,4-DIHYDROQUIINOLINE-3-CARBOXYLIC ACID DERIVATIVES AS FACTOR XIA INHIBITORS FOR TREATING FIBRINOLYTIC DISEASES

摘要

The invention relates to 7-{4-[(2S)-2-({[trans-4-(aminomethyl)cyclohexyl]carbonyl}amino)-3-(phenylamino)-3-oxopropyl]phenyl}-6-methyl-4-oxo-l,4-dihydroquinoline-3-carboxylic acid derivatives as factor Xla inhibitors for the treatment of fibrinolytic and thromboembolic diseases, in particular blood loss in hyperfibrinolytic states, in organ transplants or heart surgery interventions, in particular with a cardiopulmonary bypass, or as a constituent of a fibrin adhesive.