| 发明名称 |
ANTIBODY HAVING BROAD NEUTRALIZATION ACTIVITY AGAINST GROUP 1 INFLUENZA A VIRUSES |
| 摘要 |
From PBMCs of patients infected with H1N1pdm, three human monoclonal antibodies have been obtained which are capable of binding to an epitope present at residues 40 to 58 in an HA2 region of a hemagglutinin protein derived from H1N1pdm. Further, these antibodies have been found to also have a neutralization activity against subtype H1 and subtype H5 of group 1 influenza A viruses. On the other hand, the three antibodies have also been found to exhibit neither a binding ability nor a neutralization activity against subtype H2 which belongs to the group 1, but in the HA2 region derived from H1N1pdm of which the amino acid at residue 45 is substituted with phenylalanine and the amino acid at residue 47 is substituted with glycine. |
| 申请公布号 |
US2016264648(A1) |
申请公布日期 |
2016.09.15 |
| 申请号 |
US201415034713 |
申请日期 |
2014.11.06 |
| 申请人 |
OSAKA UNIVERSITY ;MEDICAL & BIOLOGICAL LABORATORIES CO., LTD. ;DEPARTMENT OF MEDICAL SCIENCES |
发明人 |
SASAKI Tadahiro;ONO Kenichiro;BOONSATHORN Naphatsawan;WATANABE Yohei;INOUE Yuji;IKUTA Kazuyoshi |
| 分类号 |
C07K16/10 |
主分类号 |
C07K16/10 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An antibody having a neutralization activity against subtype H1 and subtype H5 of group 1 influenza A viruses and having the following features (a) and (b):
(a) capable of binding to an epitope present at residues 40 to 58 in an HA2 region of a hemagglutinin protein derived from an A/Suita/1/200/2009 strain; and (b) not binding to the hemagglutinin protein derived from the A/Suita/1/200/2009 strain in the HA2 region of which an amino acid at residue 45 is substituted with phenylalanine and an amino acid at residue 47 is substituted with glycine. |
| 地址 |
Osaka JP |
