SUBSTITUTED SULFONAMIDE COMPOUNDS

摘要

The invention is concerned with the compounds of formula I:;;and salts thereof and other compounds of formulas II-IX as disclosed herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formulas I-IX as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain or asthma.

主权项

1. A compound of formula I: wherein:
B is B1, B2, or B3;B1 is a 5-membered heteroaryl comprising 2 nitrogen atoms in the ring, wherein each 5-membered heteroaryl is unsubstituted or substituted with one or more groups independently selected from halogen, CN, (C1-C6)alkyl, (C1-C6)haloalkyl, O(C1-C6)alkyl, and O(C1-C6)haloalkyl;B2 is phenyl, wherein each phenyl is unsubstituted or substituted with one or more groups independently selected from halogen, CN, (C1-C6)alkyl, (C1-C6)haloalkyl, O(C1-C6)alkyl, and O(C1-C6)haloalkyl;B3 is 6-membered heteroaryl, wherein each 6-membered heteroaryl is unsubstituted or substituted with one or more groups independently selected from halogen, CN, (C1-C6)alkyl, (C1-C6)haloalkyl, O(C1-C6)alkyl, O(C1-C6)haloalkyl, 5 or 6-membered heteroaryl, (C3-C7)cycloalkyl, and 4, 5, 6, or 7-membered heterocyclyl; and wherein any of the 5 or 6-membered heteroaryl, (C3-C7)cycloalkyl, or 4, 5, 6, or 7-membered heterocyclyl groups is unsubstituted or substituted with one or more groups independently selected from halogen, CN, (C1-C6)alkyl, (C1-C6)haloalkyl, O(C1-C6)alkyl, and O(C1-C6)haloalkyl;R1 is phenyl or heteroaryl, wherein each phenyl or heteroaryl is unsubstituted or substituted with one or more groups independently selected from halogen, CN, (C1-C6)alkyl, and (C1-C6)haloalkyl;R2 is (C1-C6)alkyl, (C1-C6)haloalkyl, or (C3-C7)cycloalkyl; wherein (C1-C6)alkyl is optionally substituted with O(C1-C6)alkyl;R3 is H or (C1-C6)alkyl; orR2 and R3 together with the atoms to which they are attached form a (C3)cycloalkyl;R4 is H, F, or CN;R5 is H or (C1-C6)alkyl; orone of R2 and R3 and one of R4 and R5 together with the atoms to which they are attached form a (C3)cycloalkyl;R6 is phenyl, (C3-C7)cycloalkyl, 5 or 6-membered heteroaryl, or 4, 5, 6 or 7-membered heterocycle, wherein any phenyl, (C3-C7)cycloalkyl, 5 or 6-membered heteroaryl, or 4, 5, 6 or 7-membered heterocycle of R6 is optionally substituted with one or more groups independently selected from halogen, CN, SF5, (C1-C6)alkyl, (C1-C6)haloalkyl, O(C1-C6)alkyl, or O(C1-C6)haloalkyl; orR6 is O—CH2—R7;R7 is (C1-C6)alkyl, 4, 5, 6, or 7-membered heterocycle, (C3-C7)cycloalkyl, or 6-membered heteroaryl, wherein any (C1-C6)alkyl, 4, 5, 6, or 7-membered heterocycle, (C3-C7)cycloalkyl, or 6-membered heteroaryl is optionally substituted with one or more groups independently selected from halogen, CN, (C1-C6)alkyl, (C1-C6)haloalkyl, O(C1-C6)alkyl, (C3-C7)cycloalkyl, and O(C1-C6)haloalkyl;or a salt thereof.