| 发明名称 | <i>Clostridium difficile </i>antibodies | ||
| 摘要 | Compositions and methods for the treatment or prevention of Clostridium difficile infection in a subject are provided. The compositions comprise antibodies to Clostridium difficile toxin A. The methods provide for administering the antibodies to a subject in an amount effective to reduce or eliminate or prevent relapse from Clostridium difficile bacterial infection. | ||
| 申请公布号 | US9505847(B2) | 申请公布日期 | 2016.11.29 |
| 申请号 | US201213592286 | 申请日期 | 2012.08.22 |
| 申请人 | CNJ HOLDINGS INC | 发明人 | Cassan Robyn;Berry Jody;Johnstone Darrell;Toth Derek;George Joyee Antony;Tighe Bonnie |
| 分类号 | C07K14/33;C07K16/12;A61K39/02;A61K39/08;C07K16/40;A61K39/40;A61K45/06;A61K39/00 | 主分类号 | C07K14/33 |
| 代理机构 | Thompson Coburn LLP | 代理人 | Thompson Coburn LLP |
| 主权项 | 1. An isolated monoclonal antibody, or an antigen-binding portion thereof, comprising a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises three complementarity determining regions (CDRs), CDR1, CDR2 and CDR3, having the amino acid sequences set forth in SEQ ID NOs: 29, 30 and 31, respectively, wherein the light chain variable region comprises three CDRs, CDR1, CDR2 and CDR3, having the amino acid sequences set forth in SEQ ID NOs: 21, 22 and 23, respectively; and wherein the antibody or antigen-binding portion thereof specifically binds to Clostridium difficile (C. difficile) toxin A. | ||
| 地址 | Winnipeg, MB CA | ||