发明名称 |
USE OF NITRIC OXIDE-RELEASING POLYMERS TO TREAT RESTENOSIS AND RELATED DISORDERS |
摘要 |
Methods of amelioration, treatment and prevention for restenosis and related disorders are provided. Methods involve the administration of nitric oxide by a nitric oxide delivery means comprising a restenosis-ameliorating or therapeutically/prophylactically effective amount of either a polymer to which is bound a nitric oxide-releasing N2O2- functional group a compound comprising a nitric oxide-releasing N2O2- functional group. Also provided are nitric oxide delivery means comprising such nitric oxide-releasing polymers or compounds for use in such methods. Preferably, the delivery means is coated with a nitric oxide-releasing polymer, which may be biodegradable, and enables the controllable and predictable release of NO to a given site in such a manner that effective ameliorating, prophylactic or therapeutic dosing is realized. |
申请公布号 |
EP0752866(A1) |
申请公布日期 |
1997.01.15 |
申请号 |
EP19950912871 |
申请日期 |
1995.03.09 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES;COMEDICUS, INC. |
发明人 |
KEEFER, LARRY, K.;HUTSELL, THOMAS, C. |
分类号 |
C07D295/12;A61K9/00;A61K31/44;A61K31/445;A61K31/495;A61K31/655;A61K31/785;A61K38/00;A61K47/48;A61P9/08;C07D295/22;C08F8/30 |
主分类号 |
C07D295/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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