| 发明名称 | tRNA derived small RNAs (tsRNAs) involved in cell viability | ||
| 摘要 | The present invention features compositions and methods relating to tRNA-derived small RNAs (tsRNAs). Provided herein are oligonucleotide compositions that are complementary to tsRNAs, in particular leuCAGtsRNA, and methods of using the oligonucleotides for the regulation of respective tsRNA. Further provided are methods of inducing apoptosis through the inhibition of leuCAGtsRNA. | ||
| 申请公布号 | US9428537(B2) | 申请公布日期 | 2016.08.30 |
| 申请号 | US201414214032 | 申请日期 | 2014.03.14 |
| 申请人 | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 发明人 | Kay Mark A.;Kim Hak kyun;Wang Shengchun |
| 分类号 | C07H21/04;C07H21/02;C12N15/113;A61K31/712;A61K45/06;A61K31/606;A61K31/635 | 主分类号 | C07H21/04 |
| 代理机构 | Morgan, Lewis & Bockius LLP | 代理人 | Morgan, Lewis & Bockius LLP ;Mann Jeffry S. |
| 主权项 | 1. An oligonucleotide that is complementary to a tRNA-derived small RNA (tsRNA), wherein the oligonucleotide is selected from the group consisting of:(a) tGTcAGgAgTggGaT;(SEQ ID NO: 2)and(b) GGTGtcaggagtggGATT,(SEQ ID NO: 11) wherein uppercase letters represent locked nucleic acids and lowercase letters represent unmodified nucleic acids. | ||
| 地址 | Stanford CA US | ||