Substituted pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalines for the treatment of nervous system disorders

摘要

The invention relates to particular substituted heterocycle fused gamma-carbolines, of Formula I, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving 5-HT2A receptor, serotonin transporter (SERT) and/or pathways involving dopamine D2 receptor signaling systems, such as disease of the central nervous system.;

主权项

1. A compound of formula I:wherein:
X is N(H) or N(C1-4alkyl); R1 is H or C1-6alkyl; R2 is H or OR3, wherein R3 is H or C1-6 alkyl; provided that R1 and R2 are not both H, and R1 and R3 are not both H;in free base or pharmaceutically acceptable salt form.