Substituted azoles, antiviral active component, pharmaceutical composition, method for preparation and use thereof

摘要

The present invention relates to novel antiviral active 5-{4-[1H-imidazol-5-ylaryl(or hetaryl)]-buta-1,3-diynyl}-1H-imidazoles of the general formula 1 and pharmaceutically acceptable salt thereof, pharmaceutical composition, antiviral medicament, therapeutic kit for prophylaxis and treatment of hepatisis C virus diseases, and method for prophylaxis and treatment of hepatisis C.;
wherein:

R1 and R2—represent optionally identical radicals selected from 2.1 and 2.2, where an asterisk (*) denotes the position of attachment to the imidazole fragment, (S) and (R) are types of chiral centers;
;
R3 is isopropyl or phenyl radicals;

Ar an aromatic or heteroaromatic diradical.

主权项

1. Substituted azoles of formula 1A and pharmaceutically acceptable salts thereof, wherein: solid lines with accompanying dotted lines (---) represent a single bond or a double bond, provided that if one of them is a single bond, then the other one is a double bond; X and Y have optionally different meanings and represent nitrogen atom, or a NH group; R1 and R2—represent optionally identical radicals 2.1-2.4, wherein an asterisk (*) denotes the position of attachment to the azolic fragment; A represents:
biradical selected from biradicals of formulae 3.96, 3.100, wherein an asterisk (*) denotes the positions of attachment to the azolic fragments;