发明名称 NEUREGULIN VARIANTS AND METHODS OF SCREENING AND USING THEREOF
摘要 The present invention provides polypeptide variants of neuregulin-1β (NRG-1β) that have enhanced or decreased binding affinity to ErbB3 and/or ErbB4. The invention also provides methods of screening and producing polypeptide variants of NRG-1β and methods of using polypeptide variants of NRG-1β for treating diseases.
申请公布号 US2016297859(A1) 申请公布日期 2016.10.13
申请号 US201615097198 申请日期 2016.04.12
申请人 ZENSUN (SHANGHAI) SCIENCE AND TECHNOLOGY LTD. 发明人 ZHOU Mingdong
分类号 C07K14/475;G06F19/18;G06F19/16 主分类号 C07K14/475
代理机构 代理人
主权项 1. A polypeptide variant of neuregulin-1β comprising amino acid sequence shown in SEQ ID NO:1, wherein the polypeptide variant comprises a different amino acid than that in SEQ ID NO:1, wherein the polypeptide variant has an enhanced binding affinity to ErbB3 compared to polypeptide of SEQ ID NO:1, and wherein at residue 25 said different amino acid is A, C, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W, or Y; or at residue 35 said different amino acid is A, C, D, E, F, G, H, I, L, N, M, P, Q, R, S, T, V, W, or Y; or at residue 46 said different amino acid is A, C, D, E, F, G, H, I, K, L, M, N, P, R, S, T, V, W, or Y.
地址 Shanghai CN