Poly(4-hydroxybutyrate)-B-monomethoxy(polyethylene glycol) copolymer nanoparticles, production method for same and pharmaceutical composition for brain disorder treatment containing same as active ingredient

摘要

The present invention relates to poly(4-hydroxybutyrate)-b-monomethoxy(polyethylene glycol) copolymer nanoparticles, a method for preparing the same, and a pharmaceutical composition including the same as an active ingredient for treating brain disorders, in which the P(4HB)-b-mPEG nanoparticles according to the present invention break down slowly in brain cells such that gamma-hydroxybutyric acid (GHB) is released and so can sustainedly release a therapeutic level of concentration of GHB which is used as an agent for treating brain disorders such as epilepsy, and the nanoparticles are in the form of a hydrophobic polymer and so cannot easily be used as a hallucinogenic agent or narcotic agent due to the hydrophobic property whereby said nanoparticles do not dissolve in water or alcohol, and so can be used more safely than existing GHB, and hence, can advantageously be used instead of prior-art GHB therapeutic agents.

主权项

1. A method for treating epilepsy, comprising administering to a subject in need thereof as an active ingredient, poly(4-hydroxybutyrate)-b-monomethoxy(polyethylene glycol) copolymer nanoparticle (hereinafter, P(4HB)-b-mPEG nanoparticle), wherein surface of the nanoparticle is composed of polyethylene glycol and core of the nanoparticle is composed of polyhydroxybutyrate.