METHODS FOR DIAGNOSING AND TREATING BODY WEIGHT RELATED DISORDERS IN ANIMALS

摘要

A method for determining if an animal is at risk for a body weight related disorder is described. An animal is provided and an aspect of ICAM receptor or beta 2 integrin metabolism or structure is evaluated in the animal. An abnormality in the aspect of ICAM receptor or beta 2 integrin metabolism or structure is diagnosed of being at risk for a body weight related disorder. Also described are methods for detecting the presence of a disease affecting body weight, methods for evaluating an agent for use in modulating body weight, methods for treating a body weight related disorder, methods for monitoring a therapeutic treatment of a disease affecting body weight, and methods for increasing the fat content in the liver or milk of an animal. Pharmaceutical compositions are also provided.