发明名称 |
Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives |
摘要 |
Disclosed herein are non-natural amino acids and dolastatin analogs that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The dolastatin analogs can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid dolastatin analogs and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology use. |
申请公布号 |
AU2016204454(A1) |
申请公布日期 |
2016.07.21 |
申请号 |
AU20160204454 |
申请日期 |
2016.06.28 |
申请人 |
AMBRX, INC. |
发明人 |
MIAO, ZHENWEL;ATKINSON, KYLE C.;BIROC, SANDRA;BUSS, TIMOTHY;COOK, MELISSA;KRAYNOV, VADIM;MARSDEN, ROBIN;PINKSTAFF, JASON;SKIDMORE, LILLIAN;SUN, YING;SZYDLIK, ANGIESZKA;VALENTA, IANINA |
分类号 |
C07D417/12;A61K31/427;A61P35/00;C07D207/08;C07D401/12 |
主分类号 |
C07D417/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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