发明名称 |
PEPTIDE DERIVATIVE FUSION INHIBITORS OF HIV INFECTION |
摘要 |
The claimed invention is directed toward modified HIV-1 gp41 C-terminal heptad repeat fusion inhibitors. In particular, peptide derivatives of C-34 were prepared (e.g., FB006M) and modified with 3-maleimidoproionic acid (MPA), which allows rapid and irreversible conjugation to serum albumin at a 1:1 molar ratio. These polypeptides have an extended half-life in vivo and display potent antiviral activity against HIV-1. |
申请公布号 |
EP1542718(A2) |
申请公布日期 |
2005.06.22 |
申请号 |
EP20030759385 |
申请日期 |
2003.09.23 |
申请人 |
XIE, DONG;JIANG, HE;FRONTIER BIOTECHNOLOGIES CO., LTD. |
发明人 |
XIE, DONG;JIANG, HE |
分类号 |
C07K14/16;A61K38/00 |
主分类号 |
C07K14/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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