发明名称 |
Preparation for the prophylaxis of restenose |
摘要 |
<p>A new preparation (I), comprises: (A) at least one antihyperplastic active agent (A) with a partition coefficient between butanol and water of at least 0.5, in capillary-accessible liquid form; and (B) an agent (B) for improving venous and arterial imaging. An independent claim is also included for a preparation (II) containing at least one agent (A) (with partition coefficient as above), which is applied from a catheter. ACTIVITY : Vasotropic; Cytostatic. 7-(2'',3''-Dihydroxypropoxycarbonyl)-paclitaxel) (A') (7 mg) was dissolved in ethanol then added to Ultravist (RTM; iopromide-based X-ray contrast agent; 370 mg/iodine per ml) (100 ml), to give an X-ray contrast agent (I') for restenosis prevention. In tests in anesthetized pigs with stent-induced arterial wall thickening, the degree of arterial thickening after 4 weeks in pigs treated with (I') was 50% of that in pigs treated with Ultravist (RTM) without addition of (A'). No side-effects were observed, despite the relatively high toxicity of (A'). MECHANISM OF ACTION : None given in the source material.</p> |
申请公布号 |
EP1669092(A1) |
申请公布日期 |
2006.06.14 |
申请号 |
EP20060001041 |
申请日期 |
2001.12.20 |
申请人 |
SCHERING AKTIENGESELLSCHAFT |
发明人 |
SPECK, ULRICH;SCHELLER, BRUNO |
分类号 |
A61K9/08;A61K49/04;A61F2/06;A61K9/00;A61K9/50;A61K31/337;A61K45/00;A61K45/06;A61K49/00;A61K49/18;A61L29/16;A61M25/10;A61P7/02;A61P9/10;A61P35/00;A61P43/00 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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