发明名称 |
METHODS AND COMPOSITIONS USEFUL IN GENERATING NON CANONICAL CD8+ T CELL RESPONSES |
摘要 |
Methods of inducing a CD8+ T cell response to a heterologous antigen in which at least 10% of the CD8+ T cells are MHC-E restricted are disclosed. The method involves immunizing with a CMV vector that does not express UL128 and UL130 proteins. Also disclosed are recombinant CMV vectors comprising nucleic acids encoding a heterologous protein antigen, a UL40 protein, and a US28 protein but that do not express an active UL128 and UL130 protein. Also disclosed are recombinant CMV vectors comprising nucleic acids encoding a heterologous protein antigen, but that do not express an active UL40 protein, UL128 protein, UL130 protein, and optionally a US28 protein. Also disclosed are recombinant CMV vectors comprising nucleic acids encoding a heterologous protein antigen, but that do not express an active US28 protein, UL128 protein, UL130 protein, and optionally a UL40 protein. |
申请公布号 |
WO2016130693(A9) |
申请公布日期 |
2016.09.15 |
申请号 |
WO2016US17373 |
申请日期 |
2016.02.10 |
申请人 |
OREGON HEALTH & SCIENCE UNIVERSITY;FRUEH, Klaus;PICKER, Louis;HANSEN, Scott;SACHA, Jonah |
发明人 |
FRUEH, Klaus;PICKER, Louis;HANSEN, Scott;SACHA, Jonah;MALOULI, Daniel |
分类号 |
C12N15/86;A61K48/00;A61P35/00;C07K14/705;C07K14/725;C12N5/0783;C12N15/12;C12N15/33;C12Q1/68 |
主分类号 |
C12N15/86 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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