HUMANIZED ANTI-COMPLEMENT FACTOR C1Q ANTIBODIES AND USES THEREOF

摘要

The present disclosure is directed to humanized anti-C1q antibodies and methods of using them.

主权项

1. A humanized antibody that specifically binds to a C1q protein, wherein the antibody comprises a heavy chain variable region and a human heavy chain constant region, wherein the heavy chain variable region comprises an Fab region and the heavy chain constant region comprises an Fc region, wherein the Fab region specifically binds to the C1q protein, and wherein the Fc region is incapable of: (1) binding the C1q protein, (2) inducing complement activity, (3) and/or inducing antibody-dependent cellular cytotoxicity (ADCC).