| 摘要 |
Recombinant adenovirus and methods of administration to a host are provided for eliciting immune response of the host to various pathogens. In one aspect of the invention, a vaccination method is provided for enhancing immunity of the host to the pathogen through rotation of the serotypes of the recombinant adenoviruses administered to the host. The method comprises administering to the host a first recombinant adenovirus comprising a first antigen sequence heterologous to native adenovirus and encoding a first viral antigen from the first pathogenic virus, expression of the first viral antigen by the first recombinant adenovirus eliciting an immune response directed against the first viral antigen in a host upon infection of the host by the first recombinant adenovirus; and administering to the host a second recombinant adenovirus comprising a second antigen sequence heterologous to native adenovirus and encoding a second viral antigen from the second pathogenic virus, expression of the second viral antigen by the second recombinant adenovirus eliciting an immune response directed against the second viral antigen in a host upon infection of the host by the first recombinant adenovirus. The serotype of the second recombinant adenovirus is different from that of the first recombinant adenovirus, or certain region(s) in the backbone of the second recombinant adenovirus (e.g., the fiber region) is of different serotype from the corresponding region(s) in the backbone of the first recombinant adenovirus.
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