| 摘要 |
FIELD: pharmaceutics.SUBSTANCE: invention represents a vaginal effervescent composition in solid form, containing citric acid, or malic acid, or tartaric acid, or fumaric acid or lactic acid, or mixture thereof, salt, carbonate and/or bicarbonate anion, where said salt is present in amount of 1 to 15 wt% with respect to total weight of composition, a mixture containing microcrystalline cellulose and arabinogalactan in ratio of 1:1 to 3:1 and at least one probiotic bacterial strain, having ability to reduce and/or eliminate pathogenic agents selected from a group comprising: Candida albicans, Candida glabrata, Candida parapsilosis, Candida krusei, Candida tropicalis, Gardnerella vaginalis, Trichomonas vaginalis, Neisseria gonorrhoeae, Escherichia coli, Herpex simplex and Haemophilus ducreyi, where probiotic bacterial strain belongs to at least one type selected from a group consisting of: Lactobacillus plantarum, Lactobacillus pentosus, Lactobacillus casei, Lactobacillus casei ssp.paracasei, Lactobacillus rhamnosus, Lactobacillus acidophilus, Lactobacillus delbrueckii, Lactobacillus delbrueckii ssp.bulgahcus, Lactobacillus delbrueckii ssp.delbrueckii, Lactobacillus fermentum, Lactobacillus gasseri, Lactobacillus reuteri, Bifidobacterium longum, Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium animalis ssp.lactis, Bifidobacterium adolescentis, Bifidobacterium pseudocatenulatum, Bifidobacterium eatenulatum or Bifidobacterium infantis and wherein said composition is applicable for treating vaginitis, vaginosis, candidiasis, gonorrhea, herpes and soft sore.EFFECT: invention provides improved stability and reduced tablet capping effect in process of their production, as well as complete distribution contained in composition of probiotic bacteria in vaginal cavity for fast population of vaginal epithelium.7 cl, 5 tbl |
