Quantum Cascading Laser System for Analyzing Pathogenic Microorganisms

摘要

A quantum cascading laser system for analyzing pathogenic microorganisms, where the quantum cascading laser system comprises a tunable laser unit, a beam splitter, lens, sample chamber, optical detector, data acquisition system, reference detector, and lock-in amplifier, where a computer controls the system and conducts the data analysis from the data produced from the quantum cascading laser system against a set of data derived from known pathogenic mircoorganisms to identify the pathogenic organisms in the original sample.

主权项

1. A pulsed quantum cascading laser system operating in an iterative process for analyzing the constituents in blood including pathogenic microorganisms including but not limited to bacteria, viruses, and fungi, blood composition including but not limited to glucose levels, cholesterol levels, insulin levels, and electrolytes, organic chemical compounds, inorganic chemical compounds including but not limited to explosive compounds, and elemental isotopes comprising:
A tunable laser unit, a beam splitter, lens, sample chamber, optical detector, data acquisition system, reference detector, and lock-in amplifier; wherein the tunable laser unit comprises a quantum cascading laser and a laser controller; wherein during each iteration of the pulsed quantum cascading laser system the quantum cascading laser generates a beam, the frequency and intensity of which is controlled by the laser controller; wherein the beam exits the quantum cascading laser and is received by the beam splitter, which divides the beam into two parts, part one of the beam and part two of the beam; wherein part one of the beam exits the beam splitter and enters the lens which orients the beam at the sample to be analyzed, passes through the lens and into the sample chamber where it impacts the sample; wherein a portion of part one of the beam that impacts the sample is absorbed by the sample; wherein after that portion of part one of the beam is absorbed, the sample releases energy, producing an output absorbance wave; wherein the non-absorbed portion of part one of the beam and output absorbance wave is then detected by the optical detector which creates data set 2, which is then sent to the data acquisition system; wherein part two of the beam exits the beam splitter and enters the reference detector, which identifies the frequencies of part two of the beam, as well as the intensity of part two of the beam, creating data set 3, which is fed into the data acquisition system; wherein the lock-in amplifier receives the various information including the initial frequency and intensity of the beam that exits the quantum cascading laser, which is data set 1, as well as data set 3 and data set 2, to then identify the unabsorbed portion of part one of the beam, identify the frequency and intensity of the output absorbance wave, determine and separate out that portion of the output absorbance wave that is the result of the blood plasma and water, and characterize the remaining frequencies and intensities of the output absorbance wave, the spectra; wherein the pulsed quantum cascading laser system is controlled by a computer; and wherein a computer also receives the spectra from the and then conducts the comparison of the frequencies and intensities of the spectra with a database of known spectra to characterize the pathogenic microorganisms and other trace constituents in the sample.