发明名称 |
ANTIBACTERIAL QUINOLINE DERIVATIVES. |
摘要 |
<p>The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib): the pharmaceutically acceptable acid or base addition salts thereof, the quaternary amines thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the <i>N</i>-oxide forms thereof. The claimed compounds are useful for the treatment of a bacterial disease including a mycobacterial disease, particularly those diseases caused by pathogenic mycobacteria such as <i>Mycobacterium tuberculosis</i>, <i>M. bovis, M. avium and M. marinum</i>. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of bacterial diseases and a process for preparing the claimed compounds.</p> |
申请公布号 |
MX2008001219(A) |
申请公布日期 |
2008.03.24 |
申请号 |
MX20080001219 |
申请日期 |
2006.07.26 |
申请人 |
JANSSEN PHARMACEUTICA N.V. |
发明人 |
ANDRIES, KOENRAAD JOZEF LODEWIJK MARCEL;KOUL, ANIL;GUILLEMONT, JEROME EMILE GEORGES;PASQUIER, ELISABETH THERESE JEANNE;LANCOIS, DAVID FRANCIS ALAIN |
分类号 |
C07D215/227;A61K31/47;A61P31/00;C07D215/12;C07D215/48;C07D401/04;C07D401/06;C07D401/12;C07D401/14;C07D405/06;C07D405/12;C07D413/06;C07D417/06 |
主分类号 |
C07D215/227 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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