METHODS FOR DETECTING MITOCHONDRIAL MUTATIONS DIAGNOSTIC FOR ALZHEIMER'S DISEASE AND DETERMINING HETEROPLASMY OF MITOCHONDRIAL NUCLEIC ACID

摘要

The present invention relates to methods of detecting genetic mutations in mitochondrial cytochrome oxidase c genes that segregate with Alzheimer's Disease and methods for determining the amount of heteroplasmy of mitochondrial nucleic acid. The invention provides methods for detecting such mutations, as a diagnostic for Alzheimer's Disease, either before or after the onset of clinical symptoms.