DEVICES, SYSTEMS AND METHODS FOR SEQUENCING BIOMOLECULES

摘要

The present disclosure provides a biomolecule sequencing device that includes at least one set of nano-gap electrodes arranged so that a current flows when a biomolecule contained in a sample passes in proximity to the set of nano-gap electrodes, an electrophoresis electrode pair for forming an electric field for moving the biomolecule between the electrodes of the set of nano-gap electrodes, a flow path for flowing the sample in a direction towards the nano-gap electrode pair, a flow path for flowing the sample in a direction away from the nano-gap electrode pair, a measurement unit configured to measure a tunnel current generated when the biomolecule passes between the electrodes of the nano-gap electrode pair with an electric field being formed, and an identification unit configured to sequence the biomolecule.

主权项

1. A biomolecule sequencing device, comprising:
a nano-channel that permits a sample containing a biomolecule to move through the nano-channel; a plurality of sets of nano-gap electrodes in the nano-channel, wherein each set of the plurality of nano-gap electrodes is configured to permit the detection of a current when the biomolecule contained in the sample passes through the nano-channel and in proximity to the plurality of sets of nano-gap electrodes, and wherein at least two sets of the plurality of sets of nano-gap electrodes have different inter-electrode distances along a width of the nano-channel; and a set of electrophoresis electrodes that provide an electric field to subject the biomolecule to motion through the nano-channel and in proximity to the plurality of sets of nano-gap electrodes in the nano-channel.