| 摘要 |
The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of fibromyalgia pain may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of injury, post-operative pain, osteoarthritis, rheumatoid arthritis, multiple sclerosis, spinal cord injury, migraine, HIV related neuropathic pain, post herpetic neuralgia, diabetic neuropathy, bipolar depression, stress, cancer pain, and lower back pain. |
| 主权项 |
1. A compound of Formula I: or a pharmaceutically acceptable salt, enantiomer, or stereoisomer thereof, wherein: R1 represents NULL, a is 2, 3 or 7; each b is independently 3, 5 or 6; e is 1, 2 or 6; c and d are each independently H, D, —OH, —OD, C1-C6-alkyl, —NH2 or —COCH3; R2 represents NULL, each a is independently 2, 3 or 7; each b is independently 3, 5 or 6; each e is independently 1, 2 or 6; each c and each d are each independently H, D, —OH, —OD, C1-C6-alkyl, —NH2 or —COCH3; n is independently 1, 2, 3, 4 or 5; R3 and R4 each independently represent H, D, —OCH3, —OCD3, NULL, R5 and R6 each independently represent D, —OCH3, —OCD3, NULL each a is independently 2, 3 or 7; each b is independently 3, 5 or 6; each e is independently 1, 2 or 6; each and each d are each independently H, D, —OH, —OD, C1-C6-alkyl, —NH2 or —COCH3; and each n is independently 1, 2, 3, 4 or 5. |
