IL-15 heterogeneous dimer protein and uses thereof

摘要

Disclosed are an IL-15 heterogeneous dimer protein and uses thereof. The IL-15 heterogeneous dimer protein comprises protein (I) and protein (II). The protein (I) is formed by means of reconstruction between IL-15 or a modification thereof and a first Fc modification; the protein (II) a second Fc modification, or is formed by means of reconstruction between IL-15Rα or a modification thereof and the second Fc modification; and the first Fc modification and the second Fc modification are connected in a manner of Knob-into-Hole. The IL-15 heterogeneous dimer protein has obvious tumor suppression activity, and has better bioactivity and an extended in-vivo half-life period compared with a single IL-15 molecule.