Treatment of nuclear factor (erythroid-derived 2)-like 2 (NRF2) related diseases by inhibition of natural antisense transcript to NRF2

摘要

The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Nuclear factor (erythroid-derived 2)-like 2 (NRF2), in particular, by targeting natural antisense polynucleotides of Nuclear factor (erythroid-derived 2)-like 2 (NRF2). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of NRF2.

主权项

1. A method of upregulating a function of and/or the expression of a Nuclear factor (erythroid-derived 2)-like 2 (NRF2) polynucleotide having SEQ ID NO: 1 in patient cells or tissues in vivo or in vitro comprising:
contacting said cells or tissues with at least one single stranded antisense oligonucleotide of about 16 to 34 nucleotides in length that targets and specifically hybridizes to a region of a natural antisense polynucleotide of the Nuclear factor (erythroid-derived 2)-like 2 (NRF2) polynucleotide, said natural antisense polynucleotide consisting essentially of SEQ ID NO: 9 thereby upregulating a function of and/or the expression of the Nuclear factor (erythroid-derived 2)-like 2 (NRF2) polynucleotide in patient cells or tissues in vivo or in vitro.