发明名称 |
Engineered nucleic acids and methods of use thereof |
摘要 |
Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to kill or reduce the growth of microorganisms. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent microbial infection, or to improve a subject's heath or wellbeing. |
申请公布号 |
US9464124(B2) |
申请公布日期 |
2016.10.11 |
申请号 |
US201414533264 |
申请日期 |
2014.11.05 |
申请人 |
Moderna Therapeutics, Inc. |
发明人 |
Bancel Stephane;Schrum Jason P.;Aristarkhov Alexander |
分类号 |
C07H21/02;C07H21/04;C07H21/00;C07K14/47;A61K45/06;A61K38/17;A61K38/46 |
主分类号 |
C07H21/02 |
代理机构 |
Wolf, Greenfield & Sacks, P.C. |
代理人 |
Wolf, Greenfield & Sacks, P.C. |
主权项 |
1. A pharmaceutical composition comprising:
a lipid-based nanoparticle comprising a synthetic messenger ribonucleic acid (mRNA) encoding a defensin polypeptide in an amount effective to permit production of the defensin polypeptide in a cell, wherein the synthetic mRNA comprises a translatable region that contains at least one nucleoside modification, and wherein 75-100% of uridine nucleotides in the synthetic mRNA are modified. |
地址 |
Cambridge MA US |