PROCESS FOR PRODUCING 3-DPA-LACTONE

摘要

3-DPA-lactone, which is difficult to obtain in a large amount from natural sources, can be produced from a readily available starting material in a high yield easily and selectively in fewer steps than before by protecting the 5-hydroxyl group of gamma -ribonolactone by introducing a protective group by the conventional method, adding an acid anhydride or an acyl chloride in the presence of a tertiary amine to cause beta -elimination of the 3-hydroxyl group to thereby form a double bond between the 2-carbon atom and 3-carbon atom and at the same time to acylate the 2-hydroxyl group, reducing the formed double bond by catalytic hydrogenation, and finally removing the protective group for the 5-hydroxyl group by the conventional method.