| 摘要 |
PCT No. PCT/GB93/00028 Sec. 371 Date Jul. 7, 1994 Sec. 102(e) Date Jul. 7, 1994 PCT Filed Jan. 8, 1993 PCT Pub. No. WO93/14066 PCT Pub. Date Jul. 22, 1993 <IMAGE> (II) Compounds of formula (II) wherein Ar is naphthyl, naphthylmethyl, 1,2,3,4-tetrahydronaphthyl, phenethyl, styryl, indanyl or a substituted derivative of any of the foregoing, or 3,4-dichlorophenyl, R1 is H, C1 to C6 alkyl, C1 to C6 alkenyl, cycloalkyl, -(CH2)qaryl, -(CH2)q(substituted aryl), -(CH2)qheterocyclic or -(CH2)q(substituted heterocyclic), wherein q is 0 to 4, R2 is H, methyl or ethyl, R3 is C1 to C3 alkylene or is absent, T is carboxyl, -CONR4R5 (wherein R4 and R5 are independently H or C1 to C4 alkyl), -COOR13 (wherein R13 is C1 to C4 alkyl, benzyl or substituted benzyl) or tetrazolyl, X is -C(O)- or -CH2-, and Y is -NR6R7 or -O-R6 (wherein R6 and R7 are independently H, C1 to C15 hydrocarbyl or halo-substituted C1 to C15 hydrocarbyl in which up to 6 carbon atoms may be replaced by -O-, -S-, or -NR8-(R8 being absent or selected from H, C1 to C12 hydrocarbyl, C1 to C12 hydrocarbylcarbonyl and C1 to C12 hydrocarbyloxycarbonyl), provided that neither R6 nor R7 contains a -O-O- group, and wherein R6 and R7 may be linked by a single or double bond), and pharmaceutically acceptable salts thereof are ligands at CCK and/or gastrin receptors.
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