| 摘要 |
The present invention describes Photolabile Compounds methods for use of the compounds. The Photolabile Compounds have a photoreleasable ligand, which can be biologically active, and which is photoreleased from the compound upon exposure to light. In one embodiment, the light is visible light, which is not detrimental to the viability of biological samples, such as cells and tissues, in which the released organic molecule is bioactive and can have a therapeutic effect. |
| 主权项 |
1. A compound of Formula IVa: wherein:
each L1 is independently an organic molecule having an amine group whose nitrogen atom forms a bond with Ru, wherein said organic molecule containing an amine group is selected from the group consisting of an amino acid, dopamine, GABA, serotonin, and aminobutyric acid;L2 is (R2)3P, (R2O)3P, wherein each R2 is independently —C1-C18 alkyl, or phenyl, and m is 2;R1 to R8 are independently —H, —C1-C18 alkyl; —NH2, —COOH, —(C1-C18 alkyl)-O—(C1-C18 alkyl), or —OC(O)(C1-C18 alkyl); andX is Cl−, F−, Br−, I−, PF6 CF3SO3−, (C1-C18 alkyl)-CO2−, or (C1-C18 alkyl)-SO3− provided L1 is not L2 when L1 is 4-aminopyridine. |
