发明名称 |
CRYSTALLINE FORMS OF CABOZANTINIB PHOSPHATE AND CABOZANTINIB HYDROCHLORIDE |
摘要 |
The present invention relates to crystalline forms of cabozantinib phosphoric acid salt and cabozantinib hydrochloric acid salt and to a method for their preparation. Furthermore, the invention relates to pharmaceutical compositions comprising said crystalline forms and their use as anti-cancer medicaments. Cabozantinib, i.e. N-{4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl}-N'- (4-fluorophenyl)-l,l-cyclopropanedicarboxamide is represented by the chemical structure: Formula. |
申请公布号 |
WO2016150966(A1) |
申请公布日期 |
2016.09.29 |
申请号 |
WO2016EP56267 |
申请日期 |
2016.03.22 |
申请人 |
SANDOZ AG |
发明人 |
STEFINOVIC, Marijan;SCHREINER, Erwin, Paul |
分类号 |
C07D215/22;A61K31/47;A61P35/00 |
主分类号 |
C07D215/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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